R. Aprianto

The Streptococcus pneumoniae transcriptome in patient cerebrospinal fluid identifies novel virulence factors required for meningitis

The paper uses RNA sequencing of cerebrospinal fluid from meningitis patients to identify S. pneumoniae virulence factors, finding two genes linked to increased mortality and reduced infection persistence.

Klebsiella pneumoniae OmpR facilitates lung infection through transcriptional regulation of key virulence factors

This study shows that OmpR in Klebsiella pneumoniae regulates virulence and lung infection by controlling key virulence factors and eliciting a strong host transcriptional response.

Pneumolysin promotes host cell necroptosis and bacterial competence during pneumococcal meningitis as shown by whole animal dual RNA-seq

In Vivo Dual RNA-Seq Analysis Reveals the Basis for Differential Tissue Tropism of Clinical Isolates of Streptococcus pneumoniae

This study uses dual RNA-seq to show how a single SNP in Streptococcus pneumoniae affects bacterial and host gene expression, leading to differential tissue tropism and disease outcomes.

Refining the pneumococcal competence regulon by RNA-sequencing

The paper uses RNA-seq to refine the pneumococcal competence regulon, identifying 4% of genes directly controlled by ComE/ComX and up to 17% affected overall.

High-resolution analysis of the pneumococcal transcriptome under a wide range of infection-relevant conditions

This study profiles the pneumococcal transcriptome under 22 infection-relevant conditions, revealing dynamic gene expression and identifying a new competence regulon member.

Deep genome annotation of the opportunistic human pathogen Streptococcus pneumoniae D39

This study annotates the genome of Streptococcus pneumoniae D39 using long-read sequencing and transcriptomics, identifying new genes, sRNAs, and operon structures.