Author

G. A. Needle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. C. Rathmell· 2 shared K. K. Steiner· 2 shared A. Castro· 1 shared A. Christofides· 1 shared A. Fon· 1 shared A. H. Hasty· 1 shared A. R. Patterson· 1 shared A. Sassano· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

J. C. Rathmell

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Melanoma clonal subline analysis uncovers heterogeneity-driven immunotherapy resistance mechanisms

C. Gruen, H. H. Yang, A. Sassano, E. Wu, V. Gopalan, K. L. Marie, A. Castro, F. R. Mehrabadi, C. H. Wu, I. Church, G. A. Needle, C. Smith, S. Chin, J. Ebersole, C. Marcelus, , E. Perez-Guijarro

The paper analyzes melanoma clonal sublines to uncover how intratumoral heterogeneity drives resistance to immunotherapy.

bioRxiv · Apr 3, 2023 · PreprintCancer Biology

Functional Overlap of Inborn Errors of Immunity and Metabolism Genes Define T Cell Immunometabolic Vulnerabilities

A. R. Patterson, G. A. Needle, A. Sugiura, C. Chi, K. K. Steiner, E. L. Fisher, G. L. Robertson, C. Bodnya, J. G. Markle, V. Gama, J. C. Rathmell

The paper identifies functional overlap between inborn errors of immunity and metabolism genes, revealing immunometabolic vulnerabilities in T cells.

bioRxiv · Jan 24, 2023 · PreprintImmunology

PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunity

J. E. Bader, M. M. Wolf, M. Z. Madden, B. I. Reinfeld, E. N. Arner, E. S. Hathaway, K. K. Steiner, G. A. Needle, M. D. Landis, M. A. Cottam, X. Ye, A. Christofides, V. A. Boussiotis, S. M. Haake, K. E. Beckermann, , J. C. Rathmell

This study shows obesity induces PD-1 on tumor-associated macrophages, which suppresses anti-tumor immunity by altering metabolic and functional properties of these cells.

bioRxiv · Nov 12, 2022 · PreprintImmunology