Author

V. H. Koelzer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

E. J. Mulholland· 2 shared G. N. Valbuena· 2 shared J. E. East· 2 shared N. Nasreddin· 2 shared P. D. Dunne· 2 shared S. J. Leedham· 2 shared T. Maughan· 2 shared A. Antanaviciute· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

E. J. Mulholland

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Author profile →

3 papers

Recent·Most cited

Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture

E. Gil Vazquez, N. Nasreddin, G. N. Valbuena, E. J. Mulholland, H. L. Belnoue-Davis, H. Eggington, R. O. Schenck, V. M. Wouters, P. Wirapati, K. Gilroy, T. R. M. Lannagan, D. J. Flanagan, A. K. Najumudeen, S. Omwenga, A. M. B. McCorry, , S. J. Leedham

The paper examines stem cell population dynamics in colorectal tumors, showing that CBC-RSC admixture correlates with mutations and microenvironmental changes, and is linked to chemoresistance.

bioRxiv · Jun 11, 2022Cancer Biology

Biological misinterpretation of transcriptional signatures in tumour samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data

N. C. Fisher, R. Byrne, H. Leslie, C. Wood, A. Legrini, A. Cameron, B. Ahmaderaghi, S. Corry, S. Malla, R. Amirkhah, A. McCooey, E. Rogan, K. Redmond, S. Sakhnevych, E. Domingo, , P. D. Dunne

The paper shows that transcriptional signatures in tumour samples can be misinterpreted due to stromal influences, affecting alignment with preclinical data.

bioRxiv · Apr 15, 2022 · PreprintCancer Biology

BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration

M. A. Koppens, H. Davis, G. N. Valbuena, E. J. Mulholland, N. Nasreddin, M. Colombe, A. Antanaviciute, S. Biswas, M. Friedrich, L. Lee, Oxford IBD Cohort Investigators, L. M. Wang, V. H. Koelzer, J. E. East, A. Simmons, , S. J. Leedham

This study shows that Grem1 antagonizes BMP signaling to regulate epithelial cell fate during intestinal regeneration.

bioRxiv · Jan 6, 2021Cell Biology