Author

C. Zaph

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 7 Research Focus:host-pathogen & immune response· 6 Research Focus:cell type annotation· 5 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

S. Scheer· 5 shared A. Zaini· 4 shared G. Rodrigues· 3 shared J. Ng· 3 shared J. Runting· 3 shared L. Dalit· 3 shared L. Hailes· 3 shared M. Bramhall· 3 shared

Activity by Year

2016-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersImmunology

S. Scheer

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7 papers

Recent·Most cited

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity

L. Dalit, C. W. Tan, A. A. Sheikh, R. Munnings, C. Alvarado, T. Hussain, A. Zaini, L. Cooper, A. Kirn, L. Hailes, A. Nguyen, L. Mackay, N. Harris, C. Zaph, N. L. La Gruta, , J. R. Groom

The paper identifies transcriptional modules and cytokine signaling pathways that drive functional heterogeneity in T follicular helper cells across different infections.

bioRxiv · Jun 12, 2024Immunology

Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective response

A. Zaini, L. Dalit, A. A. Sheikh, D. Thiele, Y. Zhang, J. Runting, G. Rodrigues, J. Ng, M. Bramhall, S. Scheer, L. Hailes, J. R. Groom, K. L. Good-Jacobson, C. Zaph

This study identifies distinct Tfh cell populations during chronic and acute helminth infections and shows their role in type 2 immune responses.

bioRxiv · Oct 20, 2021Immunology

c-Rel is required for IL-33-dependent activation of ILC2s

A. Zaini, T. Fulford, R. Grumont, J. Runting, G. Rodrigues, J. Ng, S. Gerondakis, C. Zaph, S. Scheer

This study identifies c-Rel as essential for IL-33-dependent activation of ILC2s, showing its role in lung inflammation and cytokine production.

bioRxiv · Feb 14, 2021Immunology

The methyltransferase DOT1L limits activation and the Th1 program in CD4+ T cells during infection and inflammation

S. Scheer, M. Bramhall, J. Runting, B. Russ, A. Zaini, J. Ellemor, G. Rodrigues, J. Ng, C. Zaph

This study shows that DOT1L limits Th1 activation and lineage stability in CD4+ T cells, with implications for immune response regulation.

bioRxiv · Jul 17, 2020 · PreprintImmunology

The histone methyltransferase DOT1L is essential for humoral immune responses

L. Kealy, A. Di Pietro, L. Hailes, S. Scheer, L. Dalit, J. Groom, C. Zaph, K. L. Good-Jacobson

This study shows that DOT1L is essential for B cell development and humoral immune responses, as its deletion leads to impaired germinal center formation and reduced antibody production.

bioRxiv · Jun 19, 2020Immunology

HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis

K. Burrows, F. Antignano, A. Chenery, V. Korinek, T. M. Underhill, C. Zaph

This study identifies HIC1 as a retinoic acid-dependent transcriptional repressor that regulates group 3 innate lymphoid cell function and intestinal immunity.

bioRxiv · Feb 13, 2017Immunology

The transcriptional repressor HIC1 regulates intestinal immune homeostasis

K. Burrows, F. Antignano, M. Bramhall, A. Chenery, S. Scheer, V. Korinek, T. M. Underhill, C. Zaph

This study identifies HIC1 as a key regulator of intestinal immune homeostasis, showing its role in T cell function and inflammation.

bioRxiv · Oct 28, 2016Immunology