Author

V. Le Joncour

University of Helsinki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Bioengineering· 1 Neuroscience· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

P. Laakkonen· 4 shared J. Merisaari· 2 shared J. Westermarck· 2 shared Cecilia Anna BrunelloiD· 1 shared D. B. Kastrinsky· 1 shared D. Sen Karaman· 1 shared E. Casals· 1 shared E. Castren· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

P. Laakkonen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

BDNF and glucocorticoids modulate neuroplasticity via direct interaction between TRKB and glucocorticoid receptors

Cecilia Anna Brunello, Marcel Gil Ortiz, Paula Pastor Muñoz, José Pedro Araújo, J.E. Cáceres Pajuelo, Juan Carlos Avila Marti, E. Lyytikäinen, M. Hansen, S. Tonelli, G. Didio, V. Le Joncour, E. Castren

This study investigates how glucocorticoids and TRKB signaling interact to modulate neuronal plasticity, finding that glucocorticoids promote TRKB dimerization and interact with TRKB to influence its activity and behavioral effects.

Journal of Biological Chemistry · Oct 1, 2026Peer-reviewedNeuroscience

Heparin-derived theranostic nanoprobes overcome the blood-brain barrier and target glioma in murine model

S. Samanta, V. Le Joncour, O. Wegrzyniak, V. Rangasami, H. Ali-Loytty, T. Hong, R. K. Selvaraju, O. Aberg, J. Hilborn, P. Laakkonen, O. P. Varghese, O. Eriksson, H. Cabral, O. P. Oommen

This study develops heparin-derived nanoprobes that cross the blood-brain barrier and target glioma in mice, showing effective imaging and therapeutic potential.

bioRxiv · Jan 7, 2022Bioengineering

Circumventing drug treatment? Polyethylenimine functionalized nanoparticles inherently and selectively kill patient-derived glioblastoma stem cells

N. Prabhakar, J. Merisaari, V. Le Joncour, M. Peurla, D. Sen Karaman, E. Casals, P. Laakkonen, J. Westermarck, J. Rosenholm

This study shows that PEI-functionalized nanoparticles selectively kill glioblastoma stem cells by lysosomal membrane rupture without affecting other cancer cells.

bioRxiv · Dec 14, 2020 · PreprintCancer Biology

Prostate Specific Membrane Antigen expression in the vasculature of primary lung carcinomas associates with faster metastatic dissemination to brain

J. Tanjore Ramanathan, S. Lehtipuro, H. Sihto, J. Tovari, L. Reiniger, V. Teglasi, J. Moldvay, M. Nykter, H. Haapasalo, V. Le Joncour, P. Laakkonen

The paper links PSMA vascular expression in primary lung carcinomas to faster brain metastasis and poorer survival.

bioRxiv · Dec 8, 2019Pathology

Monotherapy efficacy of BBB-permeable small molecule activators of PP2A in glioblastoma

J. Merisaari, O. V. Denisova, M. Doroszko, V. Le Joncour, P. Johansson, W. P. J. Leenders, D. B. Kastrinsky, Z. Nilesh, G. Narla, P. Laakkonen, S. Nelander, M. Ohlmeyer, J. Westermarck

This study shows that BBB-permeable PP2A activators reduce GB tumor growth and improve survival in mice with diverse GB subtypes.

bioRxiv · Sep 27, 2019 · PreprintCancer Biology