S. Nelander

The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states

This study identifies cell state-specific regulators of glioblastoma invasion routes using single-cell transcriptomics and spatial proteomics, showing their impact on patient survival and therapeutic potential.

Reconstructing the regulatory programs underlying the phenotypic plasticity of neural cancers

This study reconstructs regulatory programs in neural cancers using scRNA-seq data to identify therapeutic targets and transcription factors involved in tumor cell states.

Global hypo-methylation in a subgroup of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

The paper identifies a glioblastoma subgroup with global hypo-methylation and astrocytic features linked to invasion and immune changes.

Autocrine signaling explains the emergence of Allee effects in cancer cell populations

This study shows autocrine signaling can cause Allee effects in cancer cell populations, with growth rates depending on population density and death-to-proliferation ratios.

NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

The paper identifies FOSL1 as a key regulator of mesenchymal glioblastoma subtype through NF1 modulation, showing its role in plasticity and aggressiveness.

Monotherapy efficacy of BBB-permeable small molecule activators of PP2A in glioblastoma

This study shows that BBB-permeable PP2A activators reduce GB tumor growth and improve survival in mice with diverse GB subtypes.

Quantifying cell line specific proliferation and migration rates in glioblastoma cells

The paper quantifies proliferation and migration rates in glioblastoma cell lines and finds a negative correlation between these rates, supporting the Go or Grow hypothesis.

Live detection of neural stem and glioblastoma cells by an oligothiophene derivative

This study introduces p-HTMI, an oligothiophene derivative that selectively detects live human glioblastoma and neural stem cells in vitro and in vivo.