Author

Cecilia Anna Brunello

University of HelsinkiORCID 0000-0002-0301-8965Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Caroline BiojoneiD· 3 shared Eero ĊastréniD· 3 shared Plinio Cabrera CasarottoiD· 3 shared Cassiano R.A.F. DiniziD· 2 shared Cecilia CannarozzoiD· 2 shared José Pedro AraújoiD· 2 shared Katja KaurinkoskiiD· 2 shared Nina SeiffertiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersNeuroscience

Caroline BiojoneORCID

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Author profile →

4 papers

Recent·Most cited

BDNF and glucocorticoids modulate neuroplasticity via direct interaction between TRKB and glucocorticoid receptors

Cecilia Anna Brunello, Marcel Gil Ortiz, Paula Pastor Muñoz, José Pedro Araújo, J.E. Cáceres Pajuelo, Juan Carlos Avila Marti, E. Lyytikäinen, M. Hansen, S. Tonelli, G. Didio, V. Le Joncour, E. Castren

This study investigates how glucocorticoids and TRKB signaling interact to modulate neuronal plasticity, finding that glucocorticoids promote TRKB dimerization and interact with TRKB to influence its activity and behavioral effects.

Journal of Biological Chemistry · Oct 1, 2026Peer-reviewedNeuroscience

Fingolimod acutely facilitates the activation of TRKB

Cecilia Anna Brunello, José Pedro Araújo, Nina Seiffert, Katja Kaurinkoski, Plinio Cabrera Casarotto, Caroline Biojone, Eero Ċastrén

This study shows that fingolimod acutely activates TRKB through BDNF-dependent mechanisms, enhancing neuronal plasticity and normalizing fear responses in BDNF-deficient mice.

bioRxiv · Mar 2, 2026 · PreprintNeuroscience

Mutation in the TRKB cholesterol recognition site that blocks antidepressant binding does not influence the basal or BDNF-stimulated activation of TRKB

Caroline Biojone, Cecilia Cannarozzo, Nina Seiffert, Cassiano R.A.F. Diniz, Cecilia Anna Brunello, Eero Ċastrén, Plinio Cabrera Casarotto

This study shows that a TRKB mutation blocking antidepressant binding does not affect BDNF-stimulated activation or baseline TRKB function, but impairs antidepressant responses.

Cellular and Molecular Neurobiology · Dec 16, 2023Peer-reviewedNeuroscience

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

Plinio Cabrera Casarotto, Mykhailo Girych, Senem Merve Fred, Vera D. Kovaleva, Rafael Moliner, Giray Enkavi, Caroline Biojone, Cecilia Cannarozzo, Madhusmita Priyadarshini Sahu, Katja Kaurinkoski, Cecilia Anna Brunello, Anna Steinzeig, Frederike Winkel, Sudarshan S. Patil, Stefan Vestring, , Eero Ċastrén

This study identifies a direct binding of antidepressants to TRKB receptors, revealing a mechanism linking molecular interactions to antidepressant effects.

Cell · Feb 18, 2021Peer-reviewedNeuroscience