G. Narla

Cooperativity of c-MYC with Krüppel-Like Factor 6 Splice Variant 1 induces phenotypic plasticity and promotes prostate cancer progression and metastasis

This study identifies the cooperative role of c-MYC and KLF6-SV1 in promoting prostate cancer progression and metastasis through proteomic and genetic analyses in mouse models.

KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development

This study shows that KRASG12D upregulates CIP2A, which inhibits PP2A-B56α, leading to c-MYC stabilization and promoting pancreatic cancer initiation.

Small molecule mediated stabilization of PP2A modulates the Homologous Recombination pathway and potentiates DNA damage-induced cell death

This study shows that stabilizing PP2A with a small molecule enhances DNA damage-induced apoptosis in HGSC cells and xenografts, both alone and with PARPi, by inhibiting HR and targeting RAD51.

Small Molecule Activators of B56-PP2A Restore 4E-BP Expression and Function to Suppress Cap-dependent Translation in Cancer Cells

CIP2A interacts with TopBP1 and is selectively essential for DNA damage-induced basal-like breast cancer tumorigenesis

This study identifies CIP2A as a subtype-specific driver of DNA damage-induced basal-like breast cancer, showing its role in checkpoint signaling and therapeutic vulnerability.

Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing Aldob/Akt/PP2A protein complex

This study shows that loss of Aldob activates Akt, promoting hepatocellular carcinoma by destabilizing the Aldob/Akt/PP2A complex, and identifies SMAP as a potential therapeutic agent.

Monotherapy efficacy of BBB-permeable small molecule activators of PP2A in glioblastoma

This study shows that BBB-permeable PP2A activators reduce GB tumor growth and improve survival in mice with diverse GB subtypes.