V. Ntziachristos

Non-invasive optoacoustic imaging visualizes exercise-induced dermal revascularization in obese mice

The paper uses optoacoustic imaging to monitor microvascular changes in obese mice during exercise, showing improved vascular density and oxygenation in adipose tissues.

Protein-structure-sensitive mid-infrared optoacoustic microscopy enables label-free assessment of drug therapy in myeloma cells

This paper introduces a mid-infrared optoacoustic microscopy technique to label-free monitor drug therapy effects on myeloma cells by detecting intermolecular β-sheet formation.

Phase-shifting mid-infrared optothermal microscopy for wide-field hyperspectral imaging of living cells

This paper introduces PSOM, a technique for fast live-cell hyperspectral imaging with large FOVs and high confluency, achieving reduced noise and lower photodamage.

Non-invasive in-blood glucose sensing

This paper introduces a new biosensor, DIROS, for non-invasive blood glucose detection with improved accuracy over existing methods by targeting microvascular glucose in the skin.

Fast Optoacoustic Mesoscopy of Microvascular Endothelial Dysfunction in Cardiovascular Risk and Disease

This study introduces FP-RSOM to visualize and quantify skin microvascular endothelial dysfunction, showing higher sensitivity than existing methods in detecting cardiovascular risk factors.

Frequency Comb Optoacoustic Tomography

This paper introduces Frequency Comb Optoacoustic Tomography (FCOT) and demonstrates its superior signal-to-noise ratio and faster multi-spectral operation compared to traditional time-domain optoacoustics.

Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice

This study uses MSOT to non-invasively visualize lipid accumulation in mice with NAFLD, showing its potential for monitoring hepatic steatosis without contrast agents.

Multicompartmental Non-invasive Sensing of Postprandial Lipemia in Humans with Multispectral Optoacoustic Tomography

This study uses multispectral optoacoustic tomography to non-invasively measure postprandial lipemia in humans, showing significant lipid increases in various tissues after a high-fat meal.

Optoacoustic flow-cytometry with light scattering referencing

This paper introduces an optoacoustic flow cytometer (OAFC) that uses light scattering as a reference to distinguish E. coli cells based on optoacoustic properties of expressed chromoproteins with over 90% precision.

Multiplexed whole animal imaging with reversibly switchable optoacoustic proteins

The paper introduces two photochromic proteins for multiplexed in vivo optoacoustic imaging and develops software to enable temporal signal unmixing in commercial systems.

Challenging a preconception: Optoacoustic spectrum differs from the absorption spectrum of proteins and dyes for molecular imaging

The paper develops a multimodal laser spectrometer to measure optoacoustic spectra of dyes and proteins, revealing discrepancies between absorption and optoacoustic spectra and uncovering new photophysical properties.

A Sparse Deep Learning Approach for Automatic Segmentation of Human Vasculature in Multispectral Optoacoustic Tomography

This paper introduces a sparse UNET model for automatic vascular segmentation in MSOT images, achieving high accuracy and reducing manual effort.

Beyond early development: observing zebrafish over 6 weeks with hybrid optical and optoacoustic imaging

This paper introduces a hybrid imaging system to observe zebrafish development beyond the larval stage, enabling long-term studies of adult zebrafish in biomedicine.

Photoacoustic pigment relocalization sensor

This paper introduces a photoacoustic pigment relocalization sensor inspired by cuttlefish chromatophore cells to detect GPCR-mediated signaling molecules in vitro and in vivo.