V. V. Ganusov

Mathematical modeling suggests heterogeneous replication of Mycobacterium tuberculosis in rabbits

The paper uses mathematical modeling to show that Mycobacterium tuberculosis replication in rabbit lungs is heterogeneous, with subpopulations exhibiting different growth kinetics.

Mathematical modeling suggests cytotoxic T lymphocytes control growth of B16 tumor cells in collagin-fibrin gels by cytolytic and non-lytic mechanisms

The paper uses mathematical modeling to analyze CTL-tumor interactions in collagen-fibrin gels, finding that CTLs control tumor growth through both cytolytic and non-lytic mechanisms.

Brain-localized CD4 and CD8 T cells perform correlated random walks and not Levy walks

This study shows brain-localized CD4 and CD8 T cells move via correlated random walks, not Levy walks, challenging previous claims of unique movement strategies in the brain.

Need for CD8 T cell clusters to eliminate a malaria liver stage arises in part due to heterogeneity in killing efficacy of individual effector T cells

The paper uses intravital microscopy to analyze CD8 T cell clusters and their killing efficacy against malaria liver-stage parasites, finding significant variability in parasite elimination.

Mathematical modeling to guide experimental design: T cell clustering as a case study

The paper uses mathematical modeling to determine optimal experimental designs for studying T cell clustering around Plasmodium liver stages, showing how sample size and data type affect model discrimination.

Mathematical modeling suggests cooperation of plant-infecting viruses

The paper uses mathematical modeling to analyze viral infection dynamics in plants, finding evidence of cooperation between viral strains and highlighting limitations in experimental data for determining dissemination pathways.

Enhancing Quantitative and Data Science Education for Graduate Students in Biomedical Science

This paper develops a method to prioritize quantitative concepts for graduate biomedical science curricula based on faculty-identified key publications.

Platelets are dispensable for the ability of CD8+ T cells to accumulate, patrol, kill and reside in the liver

This study shows that platelets are not essential for CD8+ T cell accumulation, patrolling, killing, and residency in the liver, while ASGP-expressing cells are retained in the liver but lost from the spleen.

Correlation between speed and turning naturally arises for sparsely sampled cell movements

The paper shows that a negative correlation between cell speed and turning angle can arise from sub-sampling of cell trajectories, not necessarily from intrinsic cellular mechanisms.

A new method based on the von Mises-Fisher distribution shows that a minority of liver-localized CD8 T cells display hard-to-detect attraction to Plasmodium-infected hepatocytes

The paper introduces a method using the von Mises-Fisher distribution to analyze T cell attraction to Plasmodium-infected hepatocytes, finding that most liver-localized CD8 T cells search randomly while a minority show weak attraction.

Liver environment-imposed constraints diversify movement strategies of liver-localized CD8 T cells

This study quantifies movement patterns of liver-localized CD8 T cells in mice, showing they perform correlated random walks and Levy flights influenced by liver structure and physiology.

Clustering of activated CD8 T cells around malaria-infected hepatocytes is rapid and is driven by antigen-specific T cells

Defining kinetic properties of HIV-specific CD8+ T-cell responses in acute infection

This study analyzes the quantitative features of HIV-specific CD8+ T-cell responses over acute infection and finds little change in response breadth and no correlation with viral load.

Time intervals in sequence sampling, not data modifications, have a major impact on estimates of HIV escape rates

This study shows that time intervals between viral sequence measurements significantly affect HIV escape rate estimates, not data modifications, and suggests more frequent sampling in chronic infection could improve understanding of escape dynamics.

Kinetics of HIV-Specific CTL Responses Plays a Minimal Role in Determining HIV Escape Dynamics

This study investigates the role of CTL kinetics in HIV escape dynamics using patient data and finds that temporal dynamics of T cell responses do not significantly improve model fits for viral escape.