Author

V. Vergote

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Organism:rat· 3 Research Focus:cell type annotation· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

E. Heylen· 4 shared B. Vanmechelen· 3 shared B. Weynand· 3 shared D. Jochmans· 3 shared J. Neyts· 3 shared J. Rocha-Pereira· 3 shared K. Dallmeier· 3 shared L. Coelmont· 3 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersMicrobiology

E. Heylen

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The evolutionary history of hepaciviruses

Y. Li, M. Ghafari, A. J. Holbrook, I. Boonen, N. M. S. Amor, S. Catalano, J. P. Webster, Y. Li, H. Li, V. Vergote, P. Maes, Y. L. Chong, A. Laudisoit, P. Baelo, S. Ngoy, , P. Lemey

This study identifies novel rodent hosts of hepaciviruses, documents their diversity, and estimates the origin of the genus to be about 22 million years ago.

bioRxiv · Jun 30, 2023 · PreprintMicrobiology

The characterization of multiple novel paramyxovirus species highlights the diverse nature of the subfamily Orthoparamyxovirinae

B. Vanmechelen, S. Meurs, M. Horemans, A. Loosen, T. Joly Maes, L. Laenen, V. Vergote, F. R. Koundouno, N. Magassouba, M. K. Konde, I. S. Conde, M. W. Carroll, P. Maes

This study identifies fifteen new orthoparamyxovirus species from rodents and shrews, revealing novel genome structures and evolutionary relationships within the subfamily.

bioRxiv · Mar 10, 2022 · PreprintMicrobiology

Exploration of the Ixodes ricinus virosphere unveils an extensive virus diversity including novel Coltiviruses and other reoviruses

B. Vanmechelen, M. Merino, V. Vergote, L. Laenen, M. Thijssen, J. Marti-Carreras, E. Claerebout, P. Maes

This study explores the virosphere of Ixodes ricinus ticks in Belgium, revealing diverse viruses including novel Coltiviruses and reoviruses, with evidence of genetic reassortment in one strain.

bioRxiv · Apr 8, 2021Microbiology

Nelfinavir markedly improves lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect

C. S. Foo, R. Abdelnabi, S. J. F. Kaptein, X. Zhang, S. ter Horst, R. Mols, L. Delang, J. Rocha-Pereira, L. Coelmont, P. Leyssen, K. Dallmeier, V. Vergote, E. Heylen, L. Vangeel, A. K. Chatterjee, , J. Neyts

Nelfinavir reduces SARS-CoV-2-induced lung pathology in Syrian hamsters without affecting viral RNA or infectious titers.

bioRxiv · Feb 1, 2021 · PreprintMicrobiology

The combined treatment of Molnupiravir and Favipiravir results in a marked potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model

R. Abdelnabi, C. S. Foo, S. J. F. Kaptein, X. Zhang, L. Langendries, L. Vangeel, J. Breuer, J. Pang, R. Williams, V. Vergote, E. Heylen, P. Leyssen, K. Dallmeier, L. Coelmont, D. Jochmans, , J. Neyts

This study shows that combining Molnupiravir and Favipiravir significantly enhances antiviral efficacy against SARS-CoV-2 in hamsters, reducing viral titers by 4.5 log10 and eliminating detectable virus in 60% of treated animals.

bioRxiv · Dec 10, 2020Microbiology

Antiviral treatment of SARS-CoV-2-infected hamsters reveals a weak effect of favipiravir and a complete lack of effect for hydroxychloroquine

S. J. Kaptein, S. Jacobs, L. Langendries, L. Seldeslachts, S. ter Horst, L. Liesenborghs, B. Hens, V. Vergote, E. Heylen, E. Maas, C. De Keyzer, L. Bervoets, J. Rymenants, T. Van Buyten, H. J. Thibaut, , L. Delang

This study evaluates the antiviral effects of favipiravir and hydroxychloroquine in SARS-CoV-2-infected hamsters, finding limited efficacy for both drugs.

bioRxiv · Jun 19, 2020 · PreprintMicrobiology

STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters

R. Boudewijns, H. J. Thibaut, S. J. F. Kaptein, R. Li, V. Vergote, L. Seldeslachts, C. De Keyzer, L. Bervoets, S. Sharma, J. Van Weyenbergh, L. Liesenborghs, J. Ma, S. Jansen, D. Van Looveren, T. Vercruysse, , X. Saelens

This study shows that STAT2 signaling both restricts SARS-CoV-2 spread and causes severe pneumonia in infected hamsters.

bioRxiv · Apr 23, 2020 · PreprintMicrobiology