Author

Xiaoyu Hu

Columbia UniversityPrimary ORCID profile (0000-0002-4289-6998 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Xiaoyu HuiD2 papers · Center for Life Sciences

Biology Disciplines

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Neuroscience· 2 Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Courtney CokeriD· 2 shared Hannah Kim· 2 shared Jongwon ImiD· 2 shared Tal DaninoiD· 2 shared 진하영· 2 shared Amber L. Cramer· 1 shared Aravind SubramanianiD· 1 shared Arjun Rohit AdapaiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersSynthetic Biology

Courtney CokerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Expanding the therapeutic window of bacteria for cancer therapy

Jongwon Im, Meghna Komaranchath, Sophia Xi Windemuth, Hannah Kim, Xiaoyu Hu, Arjun Rohit Adapa, Myra Ashraf, Katherine A. Cummins, Courtney Coker, YoungUk Jang, 진하영, Kam W. Leong, Ronny Drapkin, Jeffrey N. Bruce, Peter Canoll, Tal Danino

This paper develops a tumor-targeting engineered bacterium that improves therapeutic efficacy and safety in cancer treatment.

bioRxiv · Oct 29, 2026 · PreprintSynthetic Biology

Engineered probiotics target granulomas to treat mycobacterial infection

Yu-Yu Chen, Tetsuhiro Harimoto, Gaëlle Guiewi Makafe, Courtney Coker, Hannah Kim, Jongwon Im, Yuanqi Jing, 진하영, Xiaoyu Hu, Sharicka Zutshi, Mia Ross Raneri, Brian C. Weinrick, Tal Danino

This paper engineers probiotic bacteria to target granulomas and reduce mycobacterial infection in vitro and in vivo.

bioRxiv · Oct 29, 2026 · PreprintSynthetic Biology

An induced pluripotent stem cell-based chemical genetic approach for studying spinal muscular atrophy

Richard M. Giadone, Kristina M. Holton, Xiaoyu Hu, Ted E. Natoli, Sabrina Ghosh, Stanley Gill, Nicholas Lyons, Aravind Subramanian, Lee L. Rubin

The paper uses a chemical genetic approach with induced pluripotent stem cells to screen for compounds affecting SMA neuronal gene expression, generating a queryable dataset of transcriptional profiles.

Frontiers in Neuroscience · Feb 4, 2026Peer-reviewedNeuroscience

A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal Activity

Steven C. Boggess, Vaidehi Gandhi, Ming‐Chi Tsai, Emily Marzette, Noam Teyssier, Joanna Yu-Ying Chou, Xiaoyu Hu, Amber L. Cramer, Lin Yadanar, Kunal Shroff, Claire G. Jeong, Céline Eidenschenk, Jesse E. Hanson, Ruilin Tian, Martin Kampmann

The paper develops a CRISPRi-based screening platform to identify genes affecting neuronal excitability in human iPSC-derived neurons, revealing new links to neurodegenerative and neurodevelopmental disorders.

bioRxiv · Feb 28, 2024 · PreprintNeuroscience