PDE3A-SLFN12 Molecular Glues Target Multiple KIT D816V Cell Types in Preclinical Models of Mast Cell Malignancies
Xuhuang Fu, Anne Kaiser, Payal Chawla, Axel Choidas, Peter Habenberger, Tiago Maié, Alessia Piergentili, Venkatakrishnan Harihara, Paul Wanek, Susanne Schmitz, Maximilian Ackermann, Deborah Christen, Jens Panse, Hubert Schorle, Michel Arock, , Martin Zenke
This paper identifies PDE3A-SLFN12 molecular glues as a novel therapeutic target for KIT D816V-driven mast cell malignancies, showing their efficacy in killing multiple KIT D816V cell types and synergy with tyrosine kinase inhibitors.
bioRxiv · Aug 18, 2026 · PreprintCancer Biology