Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation.
Hrishikesh S. Kulkarni, Laneshia K. Tague, Daniel R. Calabrese, Fuyi Liao, Zhiyi Liu, Lorena Garnica, Nishanth R Shankar, Xiaobo Wu, Devesha Hrishikesh Kulkarni, Aayusha Thapa, Dequan Zhou, Yan Tao, Victoria E. Davis, Cory T. Bernadt, Derek E. Byers, , Andrew E. Gelman
This study identifies a genetic variant linked to impaired complement regulation that worsens chronic lung allograft dysfunction-free survival by promoting B cell activation and donor-specific antibodies.
Journal of Clinical Investigation · Nov 11, 2025Peer-reviewedImmunology