Victoria E. DeMambro

This study identifies exosome trafficking as a key regulator of beige adipocyte thermogenesis, showing that exosome release enhances thermogenic output and energy expenditure.

This study shows that BNIP3 and mitophagy are essential for mitochondrial stress relief during osteoblast differentiation, which is necessary for maintaining bone mass in male mice.

This study shows that obesity and calorie restriction both harm bone health in mice, with calorie restriction causing more severe bone loss and metabolic changes in a sex-dependent manner.

This study shows that miR-27a and miR-27b regulate adipose thermogenesis and metabolism, with their combined loss enhancing thermogenic activity and metabolic health.

This study shows that inhibiting ACSLs in multiple myeloma cells reduces proliferation and causes mitochondrial dysfunction, suggesting ACSLs as potential therapeutic targets.

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.