Pancreatic cancer-associated organ dysfunction promotes muscle autophagy and contributes to peripheral tissue wasting
Yetiş Gültekin, Sharanya Sivanand, Kian Moritz Eghbalian, Anna M. Barbeau, Keene L. Abbott, George M. Eng, Victoria Tavernier, Brian T. Do, Heaji Shin, Elif Ozcelik, Shidong Hu, Tenzin Kunchok, Millenia Waite, William M. Rideout, Yigit Kaan Kizlier, , Matthew G. Vander Heiden
This study shows pancreatic cancer disrupts normal pancreatic function, leading to systemic nutrient depletion and muscle wasting, with autophagy in muscle playing a key role in nutrient redistribution to support tumor growth.
bioRxiv · Mar 1, 2026 · PreprintCancer Biology