Author

W. K. Lam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

M. Lazarou· 2 shared T. N. Nguyen· 2 shared A. L. Yokom· 1 shared B. S. Padman· 1 shared C. Z. Buffalo· 1 shared D. Fracchiolla· 1 shared E. Adriaenssens· 1 shared G. Khuu· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

M. Lazarou

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Author profile →

2 papers

Recent·Most cited

Unconventional Initiation of PINK1/Parkin Mitophagy by Optineurin

T. N. Nguyen, J. Sawa-makarska, G. Khuu, W. K. Lam, E. Adriaenssens, D. Fracchiolla, S. Shoebridge, B. S. Padman, M. Skulsuppaisarn, R. S. J. Lindblom, S. Martens, M. Lazarou

This study identifies an unconventional mechanism by which OPTN initiates mitophagy through TBK1 and the class III phosphatidylinositol 3-kinase complex I, distinct from the FIP200-ULK1/2 pathway.

bioRxiv · Aug 14, 2022Cell Biology

Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation

X. Ren, T. N. Nguyen, W. K. Lam, C. Z. Buffalo, M. Lazarou, A. L. Yokom, J. H. Hurley

The paper determines the structure of ATG9A's C-terminal tail interacting with the ULK1 complex's ATG13:ATG101 HORMA dimer, revealing how this interaction facilitates mitophagy.

bioRxiv · Jul 12, 2022Cell Biology