Author

D. Fracchiolla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. Martens· 3 shared C. Chang· 2 shared J. H. Hurley· 2 shared A. L. Yokom· 1 shared B. S. Padman· 1 shared E. Adriaenssens· 1 shared G. Khuu· 1 shared J. Sawa-makarska· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

S. Martens

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Unconventional Initiation of PINK1/Parkin Mitophagy by Optineurin

T. N. Nguyen, J. Sawa-makarska, G. Khuu, W. K. Lam, E. Adriaenssens, D. Fracchiolla, S. Shoebridge, B. S. Padman, M. Skulsuppaisarn, R. S. J. Lindblom, S. Martens, M. Lazarou

This study identifies an unconventional mechanism by which OPTN initiates mitophagy through TBK1 and the class III phosphatidylinositol 3-kinase complex I, distinct from the FIP200-ULK1/2 pathway.

bioRxiv · Aug 14, 2022Cell Biology

Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy

C. Chang, X. Shi, L. Jensen, A. L. Yokom, D. Fracchiolla, S. Martens, J. H. Hurley

This study investigates how different cargo receptors stimulate LC3 lipidation in selective autophagy using GUVs and shows varying requirements for autophagy core complexes.

bioRxiv · Jan 8, 2021Biochemistry

A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy

D. Fracchiolla, C. Chang, J. H. Hurley, S. Martens

The paper reconstitutes autophagy-related reactions and shows that a positive feedback loop between PI3KC3-C1 and WIPI2 accelerates LC3 lipidation.

bioRxiv · Dec 18, 2019Biochemistry