W. Ni

Jumbo phages possess independent synthesis and utilization systems of NAD+

This study identifies NAD-jumbo phages, which synthesize and utilize NAD+ for their life cycle, and finds they are widespread in various ecosystems.

SARS-CoV-2 S protein antagonizes type I interferon downstream signal pathway through interacting and attenuating phosphorylation of STAT1/STAT2

This study identifies how SARS-CoV-2 S protein inhibits type I interferon signaling by interacting with and reducing phosphorylation of STAT1/STAT2, preventing ISGF3 complex formation and ISG expression.

Construction of a potent pan-vaccine based on the evolutionary tendency of SARS-CoV-2 spike protein.

This study constructs a pan-vaccine (S6) based on the evolutionary patterns of SARS-CoV-2 spike protein to combat diverse variants, showing broader neutralization than existing vaccines.

A Population-level Strain Genotyping Method to Study Pathogen Strain Dynamics in Human Infections

This paper introduces PopMLST, a method to detect strain-level changes in bacterial infections by analyzing PCR-amplified polymorphic loci and next-generation sequencing data.

Dependency of LKB1-inactivated lung cancer on aberrant CRTC-CREB activation

This study shows that CRTC-CREB activation drives LKB1-null lung cancer growth and identifies it as a therapeutic target.

2D-HELS-AA MS Seq: Direct sequencing of tRNA reveals its different isoforms and multiple dynamic base modifications

The paper introduces 2D-HELS-AA MS Seq to directly sequence tRNA, revealing different isoforms and dynamic base modifications.