Y. Kawasaki

Paroxetine-induced transient apoptosis with delayed neurogenesis induces brain remodeling in developing zebrafish

This study shows that early paroxetine exposure in zebrafish embryos causes transient apoptosis, delayed neurogenesis, and brain remodeling linked to ASD-like social behavior impairments.

A novel sorting signal for RNA packaging into small extracellular vesicles

The paper identifies a novel RNA sorting signal in the 3UTR of RAB13 that selectively packages RNA into small extracellular vesicles.

Saccharibacteria harness light energy using Type-1 rhodopsins that may rely on retinal sourced from microbial hosts

The paper identifies Saccharibacteria using Type-1 rhodopsins that pump protons and rely on retinal from microbial hosts, suggesting a symbiotic relationship for energy generation.

Aberrant localization of CDC42 C-terminal variants to the Golgi apparatus drives pyrin inflammasome-dependent autoinflammation

This study identifies that CDC42 C-terminal variants cause aberrant Golgi localization, leading to pyrin inflammasome activation and autoinflammation.

Adaptive fitness in APC-mutant cells requires chromosome rearrangements

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

Enhanced recovery of CD9-positive extracellular vesicles from human specimens by chelating reagent

This study demonstrates that a chelating reagent improves the recovery of CD9-positive extracellular vesicles from biological samples through immunoprecipitation.

High-throughput Screening with Pluripotent Stem Cells Identifies CUDC-907 as an Effective Compound for Restoring the Proinflammatory Phenotype of Nakajo-Nishimura Syndrome

This study uses a pluripotent stem cell-derived model of Nakajo-Nishimura syndrome to identify CUDC-907 as a compound that reduces inflammatory chemokine overproduction.