Author

A. Burke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1 Ecology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:benchmarking· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. J. Eakin· 2 shared C. M. Branco· 2 shared A. C. Sherman· 1 shared A. Chang· 1 shared A. Eaton· 1 shared A. Fazal· 1 shared A. Frommlet· 1 shared A. G. Schmidt· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCell Biology

A. J. Eakin

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity

E. Nanishi, F. Borriello, T. R. O'Meara, M. E. McGrath, Y. Saito, R. E. Haupt, H.-S. Seo, S. D. van Haren, B. Brook, J. Chen, J. Diray-Arce, S. Doss-Gollin, M. De Leon, K. Chew, M. Menon, , D. J. Dowling

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

bioRxiv · May 20, 2021Immunology

Choosing optimal trigger points for ex situ, in toto conservation of single population threatened species

K. Brown, T. Tambyah, J. Fenwick, A. Burke, P. Grant, S. Hegarty-Cremer, J. Muller, M. Bode

The paper develops a decision-support tool to determine optimal trigger points for ex situ conservation of single population threatened species, using retrospective case studies to illustrate its application.

bioRxiv · Jan 8, 2021Ecology

MICROVASCULAR ENDOTHELIAL CELL ADAPTATION TO HYPOXIA IS ORGAN-SPECIFIC AND CONDITIONED BY ENVIRONMENTAL OXYGEN

M. Reiterer, A. J. Eakin, A. Burke, R. S. Johnson, C. M. Branco

This study shows that microvascular endothelial cells (MVEC) respond to hypoxia differently depending on their organ of origin and environmental oxygen levels, with mitochondrial function playing a key role in their metabolic adaptation.

bioRxiv · Aug 25, 2020Cell Biology

Circulating levels of epirubicin cause endothelial senescence while compromising metabolic activity and vascular function

A. J. Eakin, T. McErlain, A. Burke, A. Eaton, N. Tipping, G. Allocca, C. M. Branco

This study shows that low doses of epirubicin cause endothelial senescence, reduced metabolic activity, and impaired vascular function in both cell and animal models.

bioRxiv · Jun 25, 2020Cell Biology

The Structural Basis of Indisulam-Mediated Recruitment of RBM39 to the DCAF15-DDB1-DDA1 E3 Ligase Complex

D. E. Bussiere, L. Xie, W. Shu, H. Srinivas, W. Shu, A. Burke, C. Be, J. Zhao, A. Godbole, D. King, R. G. Karki, V. Hornak, F. Xu, J. Cobb, N. Carte, , J. Paulk

This study determines the structure of the DCAF15-DDB1-DDA1-Indisulam-RBM39 complex, revealing how Indisulam promotes RBM39 degradation via a novel degron motif.

bioRxiv · Aug 16, 2019Biophysics