Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism
Fadi Jacob, Sarshan R. Pather, Wei‐Kai Huang, Feng Zhang, Samuel Zheng Hao Wong, Haowen Zhou, Beatrice Cubitt, Wenqiang Fan, Catherine Z. Chen, Miao Xu, Manisha Pradhan, Daniel Y. Zhang, Wei Zheng, Anne G. Bang, Hongjun Song, , Guo‐li Ming
This study shows SARS-CoV-2 can infect brain cells and organoids derived from human induced pluripotent stem cells, leading to cell death and inflammation, and suggests using these models to study the virus's effects on the brain.
Cell stem cell · Sep 21, 2020Peer-reviewedNeuroscience