Caroline Demeret

This study investigates BANAL-236, a SARS-CoV-2-related bat virus, showing it can use human entry factors and evade human innate immunity, suggesting potential for zoonotic spillover.

This study identifies cFos as a pro-viral factor for Influenza A virus, showing it enhances cell survival and reduces interferon-β expression to facilitate viral replication.

The paper compares the modular organization of SKAP1 and SKAP2 to understand how they interact with SRC kinases and the evolutionary implications of these interactions.

This study identifies 98 UPS factors interacting with IAV NS1 proteins and functionally characterizes 18 of them to understand their role in viral immune evasion.

The paper maps binary SARS-CoV-2 protein interactions with host proteins, identifying key processes like immune signaling and ubiquitination, and suggests therapeutic targets.

Proximity-dependent biotinylation of 27 SARS-CoV-2 proteins in A549 cells maps 7810 virus-host proximity interactions across 2242 host proteins, including membrane-associated partners missed by affinity purification.

Proximity-dependent biotinylation (BioID) of 28 SARS-CoV-2 proteins in human cells maps 5,415 proximal interactions with 2,128 host targets across basal and poly(I:C) conditions.

The paper introduces an assayome concept to optimize binary interactome mapping by combining multiple assay versions, achieving high true positive detection with minimal assays.