Author

William A. MacDonald

University of PittsburghPrimary ORCID profile (0009-0002-7756-6603 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

William A. MacDonaldiD1 paper · Children's Hospital of Pittsburgh

Biology Disciplines

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Genetics· 1 Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Abby L. OlseniD· 1 shared Alan M. WatsoniD· 1 shared Alyson WangiD· 1 shared Amanda C. PoholekiD· 1 shared Ashley M. Foulkrod· 1 shared Brian D. McCabeiD· 1 shared Briana R. De MirandaiD· 1 shared Carlee R. White· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperNeuroscience

Abby L. OlsenORCID

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Author profile →

3 papers

Recent·Most cited

Characterizing spatial functional microniches with SpaceTravLR

Koushul Ramjattun, Alyson Wang, Hannah J. Lee, Shilpi Giri, Yijia Chen, William A. MacDonald, Nathan D. Lord, Amanda C. Poholek, Youjin Lee, Jishnu Das

SpaceTravLR identifies spatial functional microniches by modeling genetic perturbations across spatially resolved molecular networks, validated experimentally in a murine model.

bioRxiv · Nov 13, 2025 · PreprintSystems Biology

Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration

Silas A. Buck, Sophie A. Rubin, Tenzin Kunkhyen, Christoph D. Treiber, Xiangning Xue, Lief E. Fenno, Samuel J. Mabry, Varun R. Sundar, Zilu Yang, Divia Shah, Kyle D. Ketchesin, Darius D. Becker‐Krail, Iaroslavna Vasylieva, Megan C. Smith, Florian J. Weisel, , Zachary Freyberg

This study identifies VGLUT-mediated mechanisms protecting DA neurons from PD-related degeneration, revealing sex-specific effects and transcriptional regulators.

bioRxiv · Oct 2, 2023 · PreprintNeuroscience

Conserved mechanism of nucleoporin regulation of the Kcnq1ot1 imprinted domain with divergence in embryonic and trophoblast stem cells

Saqib S. Sachani, William A. MacDonald, Ashley M. Foulkrod, Carlee R. White, Liyue Zhang, Mellissa R.W. Mann

The paper investigates how nucleoporins regulate the Kcnq1ot1 imprinted domain in embryonic and trophoblast stem cells, finding conserved mechanisms with lineage-specific differences.

bioRxiv · Sep 29, 2018 · PreprintGenetics