Author

William C. Skarnes

Wellcome Sanger InstitutePrimary ORCID profile (0000-0002-8334-3329 · 21 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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William C. SkarnesiD21 papers · The Jackson Laboratory for Genomic Medicine

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Allan BradleyiD· 2 shared Amie Creighton· 2 shared Ann‐Marie MalloniD· 2 shared Brandon Willis· 2 shared Brendan Doe· 2 shared Colin McKerlieiD· 2 shared David J. AdamsiD· 2 shared Edward J. RyderiD· 2 shared

Activity by Year

2016-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Allan BradleyORCID

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3 papers

Recent·Most cited

Impact of Essential Genes on the Success of Genome Editing Experiments Generating 3,313 New Genetically Engineered Mouse Lines

Hillary Elrick, Kevin A. Peterson, Brandon Willis, Denise Grant Lanza, Elif Fidan Acar, Edward J. Ryder, Lydia Teboul, Petr Kašpárek, Marie‐Christine Birling, David J. Adams, Allan Bradley, Robert E. Braun, Steve D. M. Brown, Adam Caulder, Gemma F. Codner, , Valerie Laurin

The paper analyzes 3,313 genetically engineered mouse lines to identify gene essentiality as the main factor affecting Cas9-based genome editing success.

Scientific Reports · Sep 30, 2024Peer-reviewedGenetics

A resource of targeted mutant mouse lines for 5,061 genes

Marie‐Christine Birling, Atsushi Yoshiki, David J. Adams, Shinya Ayabe, Arthur L. Beaudet, Joanna R. BOTTOMLEY, Allan Bradley, Steve D. M. Brown, Antje Bürger, Wendy Bushell, Francesco Chiani, Hsian-Jean Genie Chin, Skevoulla Christou, Gemma F. Codner, Francesco John DeMayo, , Sandy Teichmann

The paper reports the generation of over 5,000 new mouse mutant strains for targeted genes, significantly expanding the available genetic resources for biomedical research.

Nature Genetics · Apr 1, 2021Peer-reviewedGenetics

Rapid, one-step generation of biallelic conditional gene knockouts

Amanda Andersson-Rolf, Roxana C. Mustata, Alessandra Merenda, Sajith Perera, Tiago Grego, Jihoon Kim, Katie Andrews, Juergen Fink, William C. Skarnes, Bon-Kyoung Koo

This paper introduces CRISPR-FLIP, a method for generating biallelic conditional gene knockouts in diploid cells using CRISPR/Cas9 and a conditional intron cassette.

bioRxiv · Jun 1, 2016 · PreprintGenetics