Dissecting mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage
Xueqing Zou, Ching Chiek Koh, Arjun Scott Nanda, Andrea Degasperi, Katie Urgo, Theodoros I. Roumeliotis, Chukwuma A. Agu, Cherif Badja, Sophie Momen, Jamie Young, Tauanne Dias Amarante, Lucy E. Side, Glen W. Brice, Vanesa Pérez‐Alonso, Daniel Rueda, , Magdalena Zarowiecki
The paper identifies gene-specific mutational signatures caused by replication errors and endogenous DNA damage using CRISPR-Cas9 knockouts and whole-genome sequencing.
Nature Cancer · Apr 26, 2021Peer-reviewedGenomics