A novel chemogenomic screening platform for scalable antimalarial drug target identification
Christopher Bower-Lepts, Mukul Rawat, William Collins Keith, Gareth Girling, Madeline R. Luth, Krypton Carolino, Katharina Boroviak, Rachael Coyle, Frank Schwach, Cindy Smidt, Ellen Bushell, Sonia Moliner Cubel, Maria De Gracia Gomez-Lorenzo, Francisco‐Javier Gamo, Elizabeth A. Winzeler, , Julian C. Rayner
This paper develops a chemogenomic platform using Plasmodium berghei artificial chromosomes to identify antimalarial drug targets through barcode sequencing and validation in Plasmodium falciparum.
bioRxiv · Aug 27, 2024 · PreprintMicrobiology