Author

William Smith

University of Leeds

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Benjamin D. TowbiniD· 1 shared Cintili Morales· 1 shared David R. WestheadiD· 1 shared Devanarayanan Siva SankariD· 1 shared Emma S. LucasiD· 1 shared Fani Deligianni· 1 shared Haidee TinningiD· 1 shared Harish Malappa Bhandari· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperCell Biology

Benjamin D. TowbinORCID

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3 papers

Recent·Most cited

Proximity labeling at H3K9me3 reveals VRK-1 regulate global chromatin distribution in C. elegans

William Smith, Valeryia Aksianiuk, Ramon Pfaendler, Rodrigo Villaseñor, Devanarayanan Siva Sankar, Michael Stumpe, Peter Lenárt, Peter Askjaer, Benjamin D. Towbin, Tuncay Baubec, Jörn Dengjel, Peter Meister

This study identifies VRK-1 as a regulator of chromatin-nuclear lamina interactions in C. elegans, showing its role in stress-induced chromatin reorganization and survival.

bioRxiv · Jul 13, 2026 · PreprintCell Biology

An evolutionarily conserved microRNA, miR-185, regulates key pathways that may contribute to implantation failure.

William Smith, Jessica C. Edge, Haidee Tinning, Zenab Butt, Fani Deligianni, Cintili Morales, Joanne Muter, Jan Joris Brosens, Mariano Mascarenhas, Harish Malappa Bhandari, Mary J. O’Connell, Emma S. Lucas, Nigel Simpson, Niamh Forde

This study shows miR-185-5p regulates pathways linked to implantation failure by altering protein expression and CNP family gene activity in endometrial cells.

bioRxiv · Jan 15, 2025 · PreprintCell Biology

Transcellular chaperone signaling is an intercellular stress-response distinct from the HSF-1 mediated HSR

Jay Miles, Sarah Townend, William Smith, David R. Westhead, Patricija van Oosten‐Hawle

The paper identifies transcellular chaperone signaling (TCS) as a gut-to-muscle stress response in C. elegans that bypasses HSF-1-mediated heat stress resistance.

bioRxiv · Mar 17, 2022 · PreprintGenetics