Dennis D. Wever

Dynamic interplay of polygenic risk across brain disorders, neuropathological endophenotypes, and neuropsychiatric symptoms

The paper integrates genotype, clinical, and neuropathological data from 2,553 donors to show genetic risk overlaps across brain disorders and neuropsychiatric symptoms.

Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimers disease

The paper identifies reduced triacylglycerols and lipid droplets in resilient Alzheimer's donors compared to AD patients, using multi-omics analysis of brain tissue.

Foamy microglia link oxylipins to disease progression in multiple sclerosis

The paper identifies foamy microglia as contributors to disease progression in secondary progressive MS, linking oxylipins to lesion expansion and proposing monoacylglycerol lipase as a therapeutic target.

Microglial states determine lesion dynamics in multiple sclerosis

The paper identifies microglial states associated with lesion expansion and remyelination in multiple sclerosis using spatial transcriptomics on human brain tissue.

Myelin speeds cortical oscillations by consolidating phasic parvalbumin-mediated inhibition

This study shows that myelination of parvalbumin-positive interneurons is essential for fast inhibition and modulation of cortical oscillations during specific behavioral states.