Xiang Wu

Large-scale all-optical electrophysiology links excitability and connectivity to circuit dynamics in vivo

The paper develops tools for large-scale all-optical electrophysiology to study neural circuit dynamics, excitability, and connectivity in vivo.

Mapping absolute membrane voltage using dynamic photocycle control

This paper introduces VMAP, a method for absolute membrane voltage imaging, and demonstrates its application in measuring drug effects, bioelectric patterns, and 3D voltage maps in zebrafish embryos.

A dendrite-resolved, in vivo transfer function from spike patterns to dendritic Ca2+

This study measures the voltage-to-Ca2+ transfer function in hippocampal CA2 pyramidal neurons during behavior and develops a biophysics-inspired model to predict Ca2+ signals from voltage waveforms.

Dendritic excitations primarily mediate back-propagation in CA1 pyramidal neurons during behavior

This study maps dendritic membrane potential dynamics in CA1 neurons during behavior, showing dendritic spikes are driven by back-propagating action potentials and influence spiking outputs and plasticity.

GrgA controls Chlamydia trachomatis growth and development by regulating expression of transcription factors Euo and HrcA

This paper shows that GrgA regulates Chlamydia trachomatis growth and development by controlling transcription factors Euo and HrcA, and a virulence factor PmpI.