Sarah E. Plutkis

The paper develops a high-throughput all-optical platform to map gene perturbations to electrophysiology using engineered hiPSCs and automated analysis.

The paper develops tools for large-scale all-optical electrophysiology to study neural circuit dynamics, excitability, and connectivity in vivo.

This paper introduces BOLT, a tool for inducible trapping, controlled release, and visualization of proteins in living cells, demonstrating its use in tracking protein and organelle dynamics.

This paper introduces a series of spontaneously blinking dyes with adjustable duty cycles for improved single-molecule localization microscopy in cells and dense structures.

This paper introduces a single-step expansion microscopy method enabling SMLM with spontaneously blinking dyes in expanded samples, achieving nanometer-resolution imaging of cellular structures.

This study measures the voltage-to-Ca2+ transfer function in hippocampal CA2 pyramidal neurons during behavior and develops a biophysics-inspired model to predict Ca2+ signals from voltage waveforms.

This study maps dendritic membrane potential dynamics in CA1 neurons during behavior, showing dendritic spikes are driven by back-propagating action potentials and influence spiking outputs and plasticity.

The paper analyzes the relative phase of membrane potential theta oscillations between hippocampal neurons during a virtual spatial task, revealing spatially coded phase shifts independent of spiking activity.

This paper introduces a method to image neuronal voltage with super-resolution beyond tissue scattering limits, achieving high precision in dense neuronal populations.

FilaBuster enables rapid, specific, and spatiotemporally controlled disassembly of intermediate filaments in living cells using a three-step photochemical strategy.

The paper investigates dendritic excitations in CA1 pyramidal neurons, showing how locally generated Na+ spikes drive history-dependent spike back-propagation and influence associative plasticity.

The paper measures voltage dynamics in dendrites of mice neurons during synaptic input integration and action potential propagation, finding shared membrane voltage and rate-dependent propagation of back-propagating action potentials.