Stabilized ion selectivity corrects activation drift in kalium channelrhodopsins
Xiao Duan, Chong Zhang, Stanislav Ott, Zhiyi Zhang, Christiane Ruse, Sven Dannhäuser, Robert Jacobi, Nadine Ehmann, Divya Sachidanandan, Georg Nagel, Manfred Heckmann, Robert J. Kittel, ALEXANDER R. GOTTSCHALK, Adam Claridge‐Chang, Shiqiang Gao
The paper identifies a KCR1 variant, C29D, that maintains stable potassium selectivity and provides reliable optogenetic inhibition across species and conditions.
Advanced Science · Nov 9, 2025Peer-reviewedNeuroscience