Author

Zhiyi Zhang

Duke-NUS Medical SchoolORCID 0000-0002-9853-9359Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:experimental assay· 3 Organism:C. elegans· 2 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:zebrafish· 1

Frequent Co-Authors

Adam Claridge‐ChangiD· 3 shared Danesha Devini SureshiD· 2 shared Jonathan AnnsiD· 2 shared Nicole MynYi LeeiD· 2 shared Stanislav OttiD· 2 shared ALEXANDER R. GOTTSCHALKiD· 1 shared Chong ZhangiD· 1 shared Christiane RuseiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersNeuroscience

Adam Claridge‐ChangORCID

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3 papers

Recent·Most cited

Brief illumination of an optoGPCR elicits prolonged inhibition of Drosophila behavior

Nicole MynYi Lee, Yishan Mai, Leif Dalberg, Jonathan Anns, Danesha Devini Suresh, Zhiyi Zhang, Adam Claridge‐Chang

The paper tests optoGPCRs in Drosophila, finding MosOPN3 provides effective, low-toxicity inhibition with brief light pulses.

bioRxiv · May 29, 2026 · PreprintNeuroscience

Stabilized ion selectivity corrects activation drift in kalium channelrhodopsins

Xiao Duan, Chong Zhang, Stanislav Ott, Zhiyi Zhang, Christiane Ruse, Sven Dannhäuser, Robert Jacobi, Nadine Ehmann, Divya Sachidanandan, Georg Nagel, Manfred Heckmann, Robert J. Kittel, ALEXANDER R. GOTTSCHALK, Adam Claridge‐Chang, Shiqiang Gao

The paper identifies a KCR1 variant, C29D, that maintains stable potassium selectivity and provides reliable optogenetic inhibition across species and conditions.

Advanced Science · Nov 9, 2025Peer-reviewedNeuroscience

Kalium channelrhodopsins effectively inhibit neurons in the small model animals

Stanislav Ott, Sangyu Xu, Nicole MynYi Lee, Ivan Hee Kean Hong, Jonathan Anns, Danesha Devini Suresh, Zhiyi Zhang, Xianyuan Zhang, Raihanah Harion, Weiying Ye, Vaishnavi Chandramouli, Suresh J. Jesuthasan, Yasunori Saheki, Adam Claridge‐Chang

This study evaluates kalium channelrhodopsins (KCRs) as optogenetic inhibitors in Drosophila, C. elegans, and zebrafish, showing they are effective and have improved properties compared to chloride-conducting ACRs.

bioRxiv · Jan 14, 2024 · PreprintNeuroscience