Chunlong Xu

This paper engineers a TnpB-ωRNA system for efficient gene editing in mice, showing improved activity over Cas12f1 and successful disease prevention in a tyrosinaemia model.

This study shows that Ptbp1 knockdown in mouse striatum using an AAV-based system does not induce astrocyte-to-neuron conversion, contrasting previous reports.

The paper designs high-fidelity Cas13 variants with minimal collateral RNA degradation effects, validated in mammalian cells and transgenic mice.

This study demonstrates the use of CasRx-mediated RNA knockdown to modulate metabolic genes in mouse liver, showing efficient and reversible reduction of PCSK9 and cholesterol levels.