Hainan Zhang

This paper develops a system to package mRNAs into AAVs, enabling efficient whole-brain mRNA delivery in mice.

This paper engineers a TnpB-ωRNA system for efficient gene editing in mice, showing improved activity over Cas12f1 and successful disease prevention in a tyrosinaemia model.

The paper introduces SPIDER, a method using pupylation and streptavidin-biotin to identify protein-biomolecule interactions, demonstrating its application in various biological contexts.

The paper designs high-fidelity Cas13 variants with minimal collateral RNA degradation effects, validated in mammalian cells and transgenic mice.

The paper identifies a novel negative feedback loop where c-di-GMP inhibits CobB activity, modulating acetyl-CoA biogenesis and YdeH stability and cyclase activity.