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Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as novel inhibitor for ELF3-MED23 Interaction

This study synthesizes and evaluates chalcone and pyrazoline derivatives as ELF3-MED23 PPI inhibitors, showing compound 10 effectively reduces HER2 levels and induces apoptosis in HER2-positive gastric cancer cells.

TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining T cell metabolic quiescence and responsiveness

This study identifies TMEM41B as an ER Ca2+ release channel that maintains T cell metabolic quiescence and responsiveness by regulating signaling pathways and receptor expression.

Liposomal Dexamethasone Reduces A/H1N1 Influenza-Associated Morbidity in Mice

This study shows that liposomal dexamethasone reduces mortality and inflammation in mice infected with A/H1N1 influenza by targeting monocyte/macrophages.

Lysosomal Exocytosis Releases Pathogenic α-Synuclein Species from Neurons

The paper identifies lysosomal exocytosis as a mechanism for releasing pathogenic α-synuclein species from neurons.

A novel vascular endothelial growth factor-trap KP-VR2 with enhanced ligand blocking

This study develops KP-VR2, a novel VEGF-Trap that neutralizes VEGF-A, VEGF-B, and PlGF, showing improved antitumor efficacy compared to existing therapies.

Fbxo45 binds SPRY motifs in the extracellular domain of N-cadherin and regulates neuron migration during brain developmen

The paper identifies Fbxo45 as a N-cadherin-binding protein that regulates neuron migration by interacting with SPRY motifs in the extracellular domain of N-cadherin.