S. Yamamoto

Fetal Kidney Transplantation for In Utero Fetuses

This paper describes a novel fetal therapy approach using transplanted fetal kidneys from different species to provide a bridge to dialysis in affected fetuses, demonstrating successful urine production and long-term function without immunosuppressants.

Flow zoometry of Drosophila

This paper introduces flow zoometry, a high-throughput screening method for Drosophila, enabling rapid, automated, and high-resolution analysis of whole animals.

Role of the medial agranular cortex in unilateral spatial neglect

This study investigates how different regions of the rodent medial agranular cortex affect unilateral spatial neglect severity and recovery.

Statistical mining of triple-negative breast cancer-specific nanobodies among huge libraries from immunized alpacas

The paper identifies nanobodies specific to triple-negative breast cancer by immunizing alpacas and screening phage libraries, showing their potential for diagnosis and targeted therapies.

The molecular mechanism for carbon catabolite repression of the chitin response in Vibrio cholerae

This paper identifies how EIIAGlc interacts with ChiS to repress chitin utilization and natural transformation in V. cholerae under glucose conditions.

Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis

This study identifies serum albumin concentration as a tertiary risk factor for dialysis-related amyloidosis, showing that maintenance dialysis improves outcomes by increasing serum component concentrations.

Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

This paper describes the discovery of S-217622, an oral non-covalent SARS-CoV-2 3CL protease inhibitor showing antiviral activity and favorable pharmacokinetics in preclinical studies.

The architecture of the actin network can balance the pushing forces produced by growing microtubules.

This study shows that actin network architecture modulates MTOC positioning by balancing pushing forces from growing microtubules.

Identification of domestic cat hepadnavirus from a cat blood sample in Japan

The study identifies a domestic cat hepadnavirus infection in a Japanese cat, showing genetic differences from global strains.

Testing the effect of oxytocin on social grooming in bonobos

This study tests if oxytocin increases social grooming in bonobos, finding an overall increase but limited individual effects.

Integrated phylogenomics and fossil data illuminate the evolution of beetles

This paper integrates phylogenomic data and fossil records to refine the evolutionary timescale and classification of beetles, revealing a late Carboniferous origin and Cretaceous diversification.

Reduction of susceptibility to azoles and 5-fluorocytosine and growth acceleration in Candida albicans by glucose in urine

This study shows that high glucose levels in urine promote Candida albicans growth and reduce susceptibility to azoles and 5-fluorocytosine.

Behavioural synchronization in a multilevel society of feral horses

The paper models behavioural synchronization in feral horses, finding that synchronization occurs both within and across social units, with stronger internal synchronization.

Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly

This study shows that centrioles and PCM cooperatively recruit CEP192 to spindle poles, promoting bipolar spindle formation in human cells.

Effects of species traits and ecosystem characteristics on species detection by eDNA metabarcoding in lake fish communities

This study evaluates how species traits and ecosystem characteristics affect eDNA detection rates in lake fish communities across Japan.

ChiS is a noncanonical DNA-binding hybrid sensor kinase that directly regulates the chitin utilization program in Vibrio cholerae

This study identifies ChiS as a noncanonical hybrid sensor kinase in Vibrio cholerae that directly regulates chitin utilization genes through DNA binding and RNA polymerase recruitment, bypassing traditional two-component signaling.

Estimating fish population abundance by integrating quantitative data on environmental DNA and hydrodynamic modelling

The paper estimates fish population abundance by integrating environmental DNA data with hydrodynamic modeling, showing results comparable to echo sounder methods.

A theory of centriole duplication based on self-organized spatial pattern formation

The paper uses super-resolution imaging and mathematical modeling to show that Plk4 self-patterning drives centriole duplication.

Self-organization of Plk4 regulates symmetry breaking in centriole duplication.

The paper shows that Plk4 self-organization drives symmetry breaking in centriole duplication by controlling its localization and activity.

Structural diversity across arbuscular mycorrhizal, ectomycorrhizal, and endophytic plant-fungus networks

This study compares the structural diversity of plant-fungus networks across different fungal groups and geographic regions in Japanese forests.

Plant-soil feedbacks between arbuscular- and ecto-mycorrhizal communities

The paper shows that mycorrhizal fungal communities influence seedling community assembly by affecting growth rates based on mycorrhizal type match/mismatch between resident plants and seedlings.