Author

J.-P. Cai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Assay:flow cytometry· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

K. K.-W. To· 4 shared K.-Y. Yuen· 4 shared H. Chu· 3 shared C. Luo· 2 shared D. Yang· 2 shared H. Huang· 2 shared I. F.-N. Hung· 2 shared J. F. W. Chan· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersImmunology

K. K.-W. To

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Three-dose vaccination-induced immune responses protect against SARS-CoV-2 Omicron-BA.2

R. Zhou, N. Liu, X. Li, Q. Peng, C.-K. Yiu, H. Huang, D. Yang, Z. Du, H.-Y. Kwok, K.-K. Au, J.-P. Cai, I. F.-N. Hung, K. K.-W. To, X. Xu, K.-Y. Yuen, Z. Chen

This study evaluates the effectiveness of three-dose SARS-CoV-2 vaccination against Omicron BA.2 breakthrough infections and finds that third-dose vaccination significantly reduces infection rates and severity.

bioRxiv · May 9, 2022 · PreprintImmunology

The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

S. Yuan, Z.-W. Ye, R. Liang, K. Tang, A. J. Zhang, G. Lu, C. P. Ong, V. K.-M. Poon, C. C.-S. Chan, B. W. Y. Mok, Z. Qin, Y. Xie, H. Sun, J. O.-L. Tsang, T. T.-T. Yuen, , J. F. W. Chan

The study compares the pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron and Delta variants in golden Syrian hamsters, finding Omicron less pathogenic but more transmissible and capable of outcompeting Delta under immune pressure.

bioRxiv · Jan 12, 2022 · PreprintMicrobiology

Vaccine-breakthrough infection by the SARS-CoV-2 Omicron variant elicits broadly cross-reactive immune responses

R. Zhou, K. K.-W. To, Q. Peng, J. M.-C. Chan, H. Huang, D. Yang, B. H.-S. Lam, V. W.-M. Chuang, J.-P. Cai, N. Liu, K.-K. Au, O. T.-Y. Tsang, K.-Y. Yuen, Z. Chen

This study examines immune responses in vaccine-breakthrough Omicron infections, finding rapid cross-reactive neutralizing antibodies and T cell responses against multiple variants.

bioRxiv · Dec 27, 2021Immunology

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

W. Qiao, H. E. Lau, H. Xie, V. K. M. Poon, C. C. S. Chan, H. Chu, S. Yuan, T. T. T. Yuen, K. K. H. Chik, J. O. L. Tsang, C. C. Y. Chan, J.-P. Cai, C. Luo, K.-Y. Yuen, K. M. C. Cheung, , K. W. K. Yeung

This study shows SARS-CoV-2 infection causes bone loss in golden Syrian hamsters through cytokine dysregulation and osteoclastogenesis.

bioRxiv · Oct 8, 2021Microbiology

Mapping the Immunodominance Landscape of SARS-CoV-2 Spike Protein for the Design of Vaccines against COVID-19

B.-z. Zhang, Y.-f. Hu, L.-l. Chen, Y.-g. Tong, J.-c. Hu, J.-p. Cai, K.-H. Chan, Y. Dou, J. Deng, H.-r. Gong, C. Kuwentrai, W. Li, X.-l. Wang, H. Chu, C.-h. Su, , J.-D. Huang

This study maps immunodominant sites on the SARS-CoV-2 spike protein using patient sera to identify potential vaccine candidates and demonstrates their neutralizing activity in mice.

bioRxiv · Apr 23, 2020 · PreprintMicrobiology