Influenza-induced activation of recruited alveolar macrophages during the early inflammatory phase drives lung injury and lethality
C. M. Koch, K. Anekalla, Y.-S. Hu, J. M. Davis, M. Ciesielski, G. Gadhvi, S.-Y. Chen, M. Turner, Y. Cheng, B. M. Coates, H. Abdala-Valencia, P. A. Reyfman, A. V. Misharin, G. S. Budinger, D. R. Winter, K. M. Ridge
This study identifies vimentin's role in driving pro-inflammatory responses in alveolar macrophages during influenza infection, linking it to lung injury and mortality.
bioRxiv · Jun 8, 2020 · PreprintImmunology