Author

Yang Dai

Salk Institute for Biological Studies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Bioinformatics· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Andrew M. LowyiD· 2 shared Dannielle D. EngleiD· 2 shared Hervé TiriaciD· 2 shared Jonathan ZhuiD· 2 shared Michael DownesiD· 2 shared Ronald M. EvansiD· 2 shared Tae Gyu OhiD· 2 shared Tony R. HunteriD· 2 shared

Activity by Year

2016-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Andrew M. LowyORCID

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Author profile →

4 papers

Recent·Most cited

HDAC Inhibition Sensitizes Pancreatic Tumors to DNA Damage by Global Redistribution of the Transcriptional Machinery

Gaoyang Liang, Hung V.‐T. Nguyen, Jonathan Zhu, Hervé Tiriac, Hadiqa Zafar, Daniel Y. Cao, Gabriela Estepa, Dylan C. Nelson, Yang Dai, Tae Gyu Oh, Christopher Liddle, Ruth T. Yu, Tony R. Hunter, Dannielle D. Engle, Reuben J. Shaw, , Ronald M. Evans

This study shows HDAC inhibition reduces DDR gene expression in pancreatic tumors by altering transcriptional machinery distribution, enhancing sensitivity to DNA damage, and introduces a nanoparticle delivery system to reduce toxicity.

Proceedings of the National Academy of Sciences · Jun 25, 2026Peer-reviewedCancer Biology

CA19-9 induces microenvironment remodeling in pancreatic ductal adenocarcinoma

Jasper Hsu, Hyemin Song, Satoshi Ogawa, Casie S. Kubota, Kristina L. Peck, Emily Jacobs, Lizmarie Garcia-Rivera, Jonathan Zhu, Yuan Sui, Woncheol Jung, Yang Dai, Jan C. Lumibao, Chelsea R. Bottomley, Kassidy Curtis, Mars Bau, , Dannielle D. Engle

This study identifies CA19-9's role in remodeling the PDAC tumor microenvironment by inducing IL1a and TGFb, leading to immunosuppressive changes that can be mitigated by blocking these factors.

bioRxiv · May 26, 2026 · PreprintCancer Biology

WEVOTE: Weighted Voting Taxonomic Identification Method of Microbial Sequences

Ahmed A. Metwally, Yang Dai, Patricia Finn, David Perkins

WEVOTE improves taxonomic classification of metagenomic reads by combining multiple methods, enhancing precision while maintaining sensitivity.

bioRxiv · Aug 11, 2016Bioinformatics

LMethyR-SVM: Predict human enhancers using low methylated regions based on weighted support vector machines

Yang Dai, Jingting Xu, Hong Hu

LMethyR-SVM predicts cell-type-specific enhancers using low methylated regions and weighted support vector machines, showing high conservation and enrichment for FANTOM5 enhancers.

bioRxiv · May 19, 2016Bioinformatics