Yasna Contreras‐Baeza

This study shows neurons switch fuel sources from glucose to lactate when extracellular lactate increases, regardless of activity, revealing lactate availability as the key factor.

This paper presents a two-point calibration protocol for the FRET indicator Pyronic to measure cytosolic pyruvate concentrations in neurons at single-cell resolution.

The paper investigates mitochondrial lactate metabolism, finding that mitochondria produce lactate as an overflow mechanism to regulate redox levels and conserve energy.