Alejandro San Martín

This study shows neurons switch fuel sources from glucose to lactate when extracellular lactate increases, regardless of activity, revealing lactate availability as the key factor.

The paper investigates the functional properties of the MPC as a pyruvate/lactate exchanger, showing it facilitates lactate efflux and participates in energy/redox venting.

This study shows that NADPH levels remain stable under acute H2O2 exposure, contradicting the proposed feedback inhibition mechanism regulating PPP flux.

This paper develops a fluorescent cell-based method to assess hNaCT citrate transport activity, enabling single-cell and high-throughput analysis.

This study examines how chronic fructose exposure alters metabolism in prostate cancer cells, revealing cell-type-specific metabolic shifts and identifying Glut-5 and lipid pathways as potential therapeutic targets.

This paper presents a two-point calibration protocol for the FRET indicator Pyronic to measure cytosolic pyruvate concentrations in neurons at single-cell resolution.

The paper shows that H2O2 increases NADPH production before depletion during oxidative stress by enhancing glucose metabolism.

The paper investigates mitochondrial lactate metabolism, finding that mitochondria produce lactate as an overflow mechanism to regulate redox levels and conserve energy.