L. Felipe Barros

Opportunistic neuronal fuelling

This study shows neurons switch fuel sources from glucose to lactate when extracellular lactate increases, regardless of activity, revealing lactate availability as the key factor.

Evolutionary history and functional divergence of hydroxycarboxylic acid receptors in primates

This study investigates the evolutionary history and functional divergence of HCAR2 and HCAR3 in primates, finding multiple duplication events in apes and functional specialization of HCAR3.

MPC is a facultative pyruvate / lactate exchanger

The paper investigates the functional properties of the MPC as a pyruvate/lactate exchanger, showing it facilitates lactate efflux and participates in energy/redox venting.

APOE genotype-dependent differences in human astrocytic energy metabolism

This study investigates how different APOE genotypes affect human astrocytic energy metabolism, finding reduced ATP production in APOE4 astrocytes but increased mitochondrial respiration and glycolytic capacity.

Lactate-carried Mitochondrial Energy Overflow

The paper investigates mitochondrial lactate metabolism, finding that mitochondria produce lactate as an overflow mechanism to regulate redox levels and conserve energy.

Potassium regulates axon-oligodendrocyte signaling and metabolic coupling in white matter

This study shows that oligodendrocytes use potassium signaling to regulate axonal metabolism and maintain axonal health through metabolic coupling.

Metabolic switch in the aging astrocyte supported via integrative approach comprising network and transcriptome analyses

The paper identifies a metabolic switch in aging astrocytes through integrative network and transcriptome analysis, revealing changes in energy metabolism and potential targets for cognitive decline prevention.

A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes

The paper shows lactate-dependent glycolysis shifts produce D-serine, linking astrocyte metabolism to synaptic and cognitive functions through CB1 receptor activation.

CO2 signalling mediates neurovascular coupling in the cerebral cortex

This study shows that CO2 signalling is critical for neurovascular coupling in the somatosensory cortex, as disrupting CO2-sensitive vasodilation or HCO3-/CO2 transport abolishes the response to neuronal activity.

Monocarboxylate Transport In Drosophila Larval Brain During Low And High Neuronal Activity

This study characterizes monocarboxylate transport in Drosophila larval brain under different activity levels, showing glial cells are more efficient in lactate/pyruvate transport and maintain a lactate gradient towards neurons.