Felipe Baeza‐Lehnert

Opportunistic neuronal fuelling

This study shows neurons switch fuel sources from glucose to lactate when extracellular lactate increases, regardless of activity, revealing lactate availability as the key factor.

Two-Point Calibration Protocol for the FRET Indicator Pyronic in Neurons

This paper presents a two-point calibration protocol for the FRET indicator Pyronic to measure cytosolic pyruvate concentrations in neurons at single-cell resolution.

Spreading depolarizations exhaust neuronal ATP in a model of cerebral ischemia

This study measures intracellular neuronal ATP changes during spreading depolarizations in cerebral ischemia models, showing ATP depletion under oxygen and glucose deprivation.

Lactate-carried Mitochondrial Energy Overflow

The paper investigates mitochondrial lactate metabolism, finding that mitochondria produce lactate as an overflow mechanism to regulate redox levels and conserve energy.

Metabolic switch in the aging astrocyte supported via integrative approach comprising network and transcriptome analyses

The paper identifies a metabolic switch in aging astrocytes through integrative network and transcriptome analysis, revealing changes in energy metabolism and potential targets for cognitive decline prevention.