Episodic Transport of Protein Aggregates Achieves a Positive Size Selectivity in Aggresome Formation
Rui Fang, Luolan Bai, Bert M. Verheijen, Boyan Li, Kevin D. Dong, João A. Paulo, Mengying Zhou, Yi-Chi Chu, Yuyu Song, Michael Y. Sherman, Steven P. Gygi, Christine M. Field, Timothy John Mitchison, Ying Lu
The paper investigates aggresome formation by reconstituting aggregate transport in Xenopus egg extract, finding that episodic dynein-mediated transport enables positive size selectivity.
Nature Communications · Aug 22, 2025Peer-reviewedCell Biology