Yosef Yarden

The paper identifies NRG1/HER3 axis activation via NE-like/EMT dedifferentiation as a mechanism of EGFR inhibitor resistance in NSCLC and shows that combining EGFR inhibition with NRG1 neutralization can eradicate tumors.

This study identifies GLYATL1 as a mediator of endocrine resistance in luminal breast cancer by promoting metabolic and epigenetic changes that counteract estrogen deprivation.

This study develops a bispecific antibody targeting MERTK and EGFR to overcome drug resistance in lung cancer with mutations in exons 19, 20, and 21.

This study shows that Mbd2 deficiency in mice leads to cognitive and social deficits, altered gene expression, and DNA methylation patterns similar to those in ASD, suggesting Mbd2 is an epigenetic regulator of ASD-risk genes.