Z. Deng

This paper introduces A-Star, a method for detecting rare mutations with high sensitivity and multiplexing capability, achieving detection as low as 0.01% allele frequency.

A murine model of COPA syndrome shows that thymic tolerance defects lead to T cell-mediated autoimmunity and lung disease similar to human patients.

This study shows that preventing PPARγ S273 phosphorylation reduces insulin resistance without weight gain or side effects, identifying Gdf3 as a key mediator.

This study presents cryo-EM structures of pannexin 1 from Xenopus tropicalis and Homo sapiens, revealing its heptameric architecture and molecular sieve mechanism for ATP release.

This paper investigates the biosynthesis of formycin A and pyrazofurin A, identifying key enzymes and pathways involved in their C-nucleoside scaffold construction.

This study adapts base editors to Streptomyces, achieving high-efficiency genome editing without DNA double-strand breaks.

The paper demonstrates an in vivo platform using promiscuous terpene synthases and prenyltransferases to generate diverse terpenoids, including novel ring systems.