Author

Z. P. Tolstyka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

C. A. Lyssiotis· 3 shared H.-J. Lee· 2 shared L. Zhang· 2 shared A. C. Kimmelman· 1 shared A. Carugo· 1 shared A. Iuga· 1 shared A. K. Deem· 1 shared A. Ma· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

C. A. Lyssiotis

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3 papers

Recent·Most cited

Medium-chain acyl-CoA dehydrogenase, a gatekeeper of mitochondrial function in glioblastoma multiforme

F. Puca, F. Yu, C. Bertolacci, P. Pettazzoni, A. Carugo, E. Huang-Hobbs, J. Liu, C. Zanca, F. Carbone, E. Del Poggetto, J. Gumin, P. Dasgupta, S. Seth, F. F. Lang, E. Sulman, , G. Draetta

This study identifies MCAD as a critical enzyme for fatty acid metabolism in GBM, showing its essential role in preventing mitochondrial damage and apoptosis.

bioRxiv · Sep 28, 2020 · PreprintCancer Biology

Tissue of Origin Dictates GOT1 Dependence and Confers Synthetic Lethality to Radiotherapy

B. S. Nelson, L. Lin, D. M. Kremer, C. M. Sousa, C. Cotta-Ramusino, A. Myers, J. Ramos, T. Gao, I. Kovalenko, K. Wilder-Romans, J. Dresser, M. Davis, H.-J. Lee, Z. C. Nwosu, S. Campit, , C. A. Lyssiotis

The paper shows that pancreatic ductal adenocarcinoma (PDA) is more dependent on GOT1 than colorectal cancer (CRC) and that GOT1 inhibition synergizes with radiotherapy to inhibit PDA growth.

Cancer & Metabolism · Jan 2, 2020Peer-reviewedCancer Biology

Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import

M. A. Badgley, D. Kremer, H. C. Maurer, K. E. DelGiorno, H.-J. Lee, V. Purohit, I. Sagalovskiy, A. Ma, J. Kapillian, C. E. M. Firl, A. R. Decker, S. A. Sastra, C. F. Palermo, L. R. Andrade, P. Sajjakulnukit, , K. P. Olive

The paper shows that targeting cystine import induces ferroptosis in pancreatic tumors, leading to tumor regression and improved survival in a mouse model.

bioRxiv · Nov 1, 2019 · PreprintCancer Biology