tRNA thiolation defects disrupt cellular proteostasis and tissue homeostasis in mammals
Lukas Englmaier, Marta Walczak, Daniel Malzl, Cristián Eggers, Felix Eichin, Valentina C. Sladky, Filip Gallob, Yevheniia Tyshchenko, Zarghun Zarif, Thomas Kolbe, Lama AlAbdi, Jörg Menche, Nathalie Spassky, Stephan Geley, Walter Rossmanith, , Andreas Villunger
This study shows that tRNA thiolation defects in humans cause proteostasis and tissue homeostasis issues, but mice with similar defects develop normally.
bioRxiv · Oct 24, 2025 · PreprintCell Biology