Inhibition of V-ATPase function drives apoptosis via GCN1/GCN2 kinase signaling
Filip Gallob, Severin Lechner, Dominika Tučková, Petra Divoká, Yevheniia Tyshchenko, Danica Drpic, Jan Hájek, Lukas Englmaier, Kateřina Delawská, Miriam M. Unterlass, Mariana de Araujo, Georg E. Winter, Pavel Hrouzek, Andreas Villunger
The paper identifies V-ATPase inhibition as a trigger for apoptosis via GCN1/GCN2 kinase signaling and MCL-1 depletion, revealing a therapeutic target in certain cancers.
bioRxiv · Mar 28, 2026 · PreprintCell Biology